Bus from Buffalo to Syracuse
Book your bus ticket to Syracuse from Buffalo today
Duration 3 hours 55 minutes (fastest time)
Departures Up to 1 service per day
Why travel with megabus?
Power outlets onboard*
Express service
Green certified
* Subject to availability
Buffalo to Syracuse bus details
Our route M24 bus stops at 4 stops between Buffalo and Syracuse. The bus sets off from Buffalo - Downtown Terminal and drops you off at Syracuse Regional Transit Center
Buffalo
Arrivals and departures are located at gate 13 in the Metropolitan Transportation Center terminal building at 181 Ellicott Street.
Plan your bus trip to Buffalo
Plan your bus trip to Buffalo
Syracuse
Arrivals and departures are located at the curbside in front of the William F Walsh Regional Transportation Center on the north side of the city. Connections are available to the CENTRO regional bus system.

Our Buses
We are very proud of our fleet of state of the art buses.
- Individual power outlets*
- Reclining seats
- Reserved seating
- Onboard Restrooms
- Travel in luxury with megabus
* Subject to availability
Frequently Asked Questions
How long does it take to travel from Buffalo to Syracuse by bus?
The fastest bus from Buffalo to Syracuse takes 3 hours 55 minutes
When is the first bus from Buffalo to Syracuse?
The earliest bus from Buffalo to Syracuse leaves at 10:00 AM
When is the last bus from Buffalo to Syracuse?
The latest bus from Buffalo to Syracuse leaves at 10:00 AM
How many daily bus trips are there from Buffalo to Syracuse?
Megabus runs up to 1 trips per day from Buffalo to Syracuse